1. Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

    Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

    A swept-source dual-wavelength photothermal (DWP) optical coherence tomography (OCT) system is demonstrated for quantitative imaging of microvasculature oxygen saturation. DWP-OCT is capable of recording three-dimensional images of tissue and depth-resolved phase variation in response to photothermal excitation. A 1,064-nm OCT probe and 770-nm and 800-nm photothermal excitation beams are combined in a single-mode optical fiber to measure microvasculature hemoglobin oxygen saturation ( SO 2 ) levels in phantom blood vessels with a range of blood flow speeds (0 to 17     mm / s ). A 50- μ m-diameter blood vessel phantom is imaged, and SO 2 levels are measured using DWP-OCT and compared with ...

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