1. Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques

    Lesion Size Detection in Geographic Atrophy by Polarization-sensitive Optical Coherence Tomography and Correlation to Conventional Imaging Techniques

    Purpose: To investigate the reproducibility of automated lesion size detection in patients with geographic atrophy (GA) using polarization-sensitive spectral domain-OCT (PS-OCT) and to compare findings with scanning laser ophthalmoscopy (SLO), fundus autofluorescence (FAF), and intensity based SD-OCT. Methods: 29 eyes of 22 patients with GA were examined by PS-OCT, selectively identifying the retinal pigment epithelium (RPE). A novel segmentation algorithm was applied, automatically detecting and quantifying areas of RPE atrophy. The reproducibility of the algorithm was assessed and lesion sizes were correlated with manually delineated SLO, FAF and intensity based SD-OCT images to validate the clinical applicability of PS-OCT in ...

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