1. Intravascular optical technology to enable comprehensive in vivo coronary pathology

    Intravascular optical technology to enable comprehensive in vivo coronary pathology

    A single intracoronary optical device yields concurrent and combined microstructural and fluorescence information from luminal samples, such as arterial tissue. Cardiovascular disease is the leading cause of mortality in the United States (777,000 cases in 2010). 1 In a large percentage of patients, the first occurrence of coronary artery disease is either sudden death or acute myocardial infarction. Approximately 20–30% of the patients with acute myocardial infarction die before they get to a hospital. It is known that certain unstable atherosclerotic plaques, called vulnerable plaques, give rise to acute coronary events. Plaque stability is dependent on various factors ...

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