Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract
Background This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT). Methods An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an “unblinded” investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 “blinded” investigators. Forty-eight images underwent retrospective image analysis. Results Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the ...
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