Assessment of retinal morphology with spectral and time domain OCT in the phase III trials of enzymatic vitreolysis
To determine the relative ability of time domain (TD) optical coherence tomography (OCT) compared with spectral domain (SD) OCT to assess vitreoretinal interface abnormalities and pharmacologic treatment of symptomatic vitreomacular adhesion (VMA)/traction (VMT) with or without full-thickness macular hole (FTMH), and the reproducibility of trained readers' evaluation of these images in an interventional phase III program of ocriplasmin. METHODS: Eyes from the MIVI-TRUST program with concurrent SD-OCT and TD-OCT at baseline and day 28 were included. Pairwise inter-modality agreement frequency and inter-reader reproducibility were calculated for baseline OCT features and the study endpoints of VMA resolution and FTMH closure ...
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