1. Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

    Quantitative optical coherence tomography of fluid-filled oral mucosal lesions

    The decision of selecting the most representative site for the biopsy of fluid-filled lesions can be difficult. This may be attributed to the poor delineation of the correct lesional site by clinical observation alone. In this study, optical coherence tomography is used to quantify the contrast between solid- and fluid-filled lesions by measuring the light intensity change at the tissue–fluid interface (intensity drop). This parameter was measured from sequential axial scans (n ≈ 106 per sample) of 3D optical coherence tomography (OCT) datasets from control tissues (n = 14) and fluid-filled lesions (n = 7) and displayed as a 2D-scaled intensity drop ...

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