Progression of an acquired vitelliform lesion to a full-thickness macular hole documented by eye-tracked spectral-domain optical coherence tomography
Vitelliform lesions (VLs), classically seen in young patients in autosomal dominant Best disease, are also seen as acquired lesions in entities such as adult-onset foveomacular vitelliform dystrophy, cuticular drusen, and central serous chorioretinopathy. These lesions appear as round yellowish deposits of material exhibiting hyperautofluorescence with fundus autofluorescence imaging. Spectral-domain optical coherence tomography (SD-OCT) shows hyperreflective material in the subretinal space, often with focal thickening at the level of the retinal pigment epithelium.1 The natural course of these lesions is often a gradual reduction in lesion size with fragmentation and resorption of the vitelliform material and eventual photoreceptor disruption and ...
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