1. Identification of muscle necrosis in mdx mice using optical birefringence imaging

    Identification of muscle necrosis in mdx mice using optical birefringence imaging

    Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy, resulting in muscle degeneration and necrosis. Healthy skeletal muscle has a high degree of birefringence, caused by the regular arrangement of myofibrils. Birefringence decreases when the muscle becomes inflamed or necrotic and this arrangement breaks down. Hence birefringence is usable as a source of image contrast for identifying regions of damage. The mdx mouse is a well-established animal model for DMD. Assessment of the extent of muscle damage and necrosis in these mice is performed by analysis of histological sections, but this requires excision and fixation of the tissue ...

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