Corneal Epithelial Thickness Mapping by Fourier-Domain Optical Coherence Tomography in Normal and Keratoconic Eyes

Objective To map the corneal epithelial thickness with Fourier-domain optical coherence tomography (OCT) and to develop epithelial thickness–based variables for keratoconus detection. Design Cross-sectional observational study. Participants One hundred forty-five eyes from 76 normal subjects and 35 keratoconic eyes from 22 patients. Methods A 26 000-Hz Fourier-domain OCT system with 5-μm axial resolution was used. The cornea was imaged with a Pachymetry+Cpwr scan pattern (6-mm scan diameter, 8 radials, 1024 axial-scans each, repeated 5 times) centered on the pupil. Three scans were obtained at a single visit in a prospective study. A computer algorithm was developed to ...
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