1. Characterization of flowing blood optical property under various fibrinogen levels using optical coherence tomography

    Characterization of flowing blood optical property under various fibrinogen levels using optical coherence tomography

    The feasibility of characterization of human blood fibrinogen levels using optical coherence tomography (OCT) was investigated. Three groups of blood samples were reconstituted of red blood cells and, I. phosphate buffered saline, II. plasma with its intrinsic fibrinogen removed and commercial fibrinogen added, III. native plasma with various fibrinogen levels (0-12 g/L). OCT signal slope (OCTSS) of blood was extracted from OCT depth-reflectivity profiles. Effects of hematocrit (HCT) and blood flow on OCTSS of the blood under various fibrinogen concentrations were also studied. The results of blood flowing at 5 mm/sec showed that OCTSS of all the three ...

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