1. Optical Coherence Tomography-Derived Anatomical Criteria for Functionally Significant Coronary Stenosis Assessed by Fractional Flow Reserve

    Optical Coherence Tomography-Derived Anatomical Criteria for Functionally Significant Coronary Stenosis Assessed by Fractional Flow Reserve

    Background: For the identification of functionally significant coronary artery disease, there have not been any dedicated optical coherence tomography (OCT) studies reported previously, although OCT can clearly detect coronary vessel lumina at higher resolution than intravascular ultrasound (IVUS). Methods and Results: OCT and fractional flow reserve (FFR) measurements were performed in 62 intermediate coronary lesions in 59 patients. FFR was calculated as the ratio of distal coronary pressure divided by proximal coronary pressure during maximal hyperemia. FFR <0.75 was used as the threshold for diagnosing functionally significant stenosis. Minimal lumen area (MLA), minimal lumen diameter (MLD) and percent lumen ...

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