Dual Window Dual Bandwidth Spectroscopic Optical Coherence Tomography Metric for Qualitative Scatterer Size Differentiation in Tissues
This work investigates the autocorrelation bandwidths of dual window (DW) optical coherence tomography (OCT) k-space scattering profile of different-sized microspheres and their correlation to scatterer size. A dual bandwidth (DB) spectroscopic metric defined as the ratio of the 10% to 90% autocorrelation bandwidths is found to change monotonically with microsphere size and gives the best contrast enhancement for scatterer size differentiation in the resulting spectroscopic image. A simulation model supports the experimental results and revealed a trade-off between the smallest detectable scatterer size and the maximum scatterer size in the linear range of the DWDB metric, which depends on the ...
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