Methods and devices for image-guided manipulation or sensing or anatomic structures

Forward-looking ultrasound transducers are positioned at the tip of a transseptal catheter to facilitate transseptal puncture and interventions within the left atrium, pulmonary veins and mitral valve. Catheter devices and systems are guided by forward-looking ultrasound or optical coherence tomography imaging for penetrating from one location within a mammalian patient's body to another location, and/or performing diagnostic or therapeutic interventions. A penetrator, diagnostic, or interventional device (eg. probe, biopsy apparatus, electrode, needle) is positioned at the catheter tip and is advanceable from the catheter to a target location outside of the lumen in which the catheter is positioned ...

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