1. Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation [Research Letters]

    Adaptive Optics and Spectral-Domain Optical Coherence Tomography of Human Photoreceptor Structure After Short Pascal Macular Grid and Panretinal Laser Photocoagulation [Research Letters]

    To understand the effect of therapeutic doses of laser application on the neurosensory retina, detailed histologic1-3 and optical coherence tomographic (OCT)4-10 evaluations have been used in both animal models and the human eye. We sought to evaluate photoreceptor structure associated with laser photocoagulation lesions using 2 high-resolution retinal imaging tools: adaptive optics (AO) and spectral-domain OCT (SD-OCT). Methods Two patients received short-duration (20-millisecond) Pascal laser therapy (532 nm; OptiMedica Corp) for clinical indications. Subject 1 was a 57-year-old woman with macular edema from hemicentral retinal vein occlusion. Treatment consisted of 3 x 3 grid laser applications with a 100-μm ...

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