1. Diagnostic Ability of a Linear Discriminant Function for Spectral-Domain Optical Coherence Tomography in Patients with Multiple Sclerosis

    Diagnostic Ability of a Linear Discriminant Function for Spectral-Domain Optical Coherence Tomography in Patients with Multiple Sclerosis

    Purpose To calculate and validate a linear discriminant function (LDF) for spectral-domain optical coherence tomography (OCT) to improve the diagnostic ability of retinal nerve fiber layer (RNFL) thickness parameters for the detection of multiple sclerosis (MS). Design Observational cross-sectional study. Participants Patients with multiple sclerosis (n = 115) and age-matched healthy subjects (n = 115) were enrolled in the study. Methods The Spectralis OCT system (Heidelberg Engineering, Heidelberg, Germany) was used to obtain the circumpapillary RNFL thickness in both eyes of each participant. Main Outcome Measures A validating set including 60% of the study subjects (69 healthy individuals and 69 patients with ...

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