1. Microfluidic Phenotyping of Cilia-Driven Mixing for the Assessment of Respiratory Diseases

    Microfluidic Phenotyping of Cilia-Driven Mixing for the Assessment of Respiratory Diseases

    The function of ciliated surfaces to clear mucus from the respiratory system is important for many respiratory diseases and, therefore, has a high impact on public health. In this work, we present a quantitative method to evaluate mixing efficiency of cilia-driven microfluidic flow based on front line deformation as an integrated measurement of cilia function. So far, mixing efficiency has been used mainly for analyzing artificial cilia. Most of this work, however, was either bound to specific imaging modalities or done on simulated data. In this simulations, mixing efficiency has been quantified as the change in length of a virtual ...

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