1. In-vivo imaging of inner retinal cellular morphology with adaptive optics-optical coherence tomography: challenges and possible solutions

    In-vivo imaging of inner retinal cellular morphology with adaptive optics-optical coherence tomography: challenges and possible solutions

    Recent progress in retinal image acquisition techniques, including optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), combined with improved performance of adaptive optics (AO) instrumentation, has resulted in improvement in the quality of in vivo images of cellular structures in the outer layers of the human retina. Despite the significant progress in imaging cone and rod photoreceptor mosaics, visualization of cellular structures in the inner retina has been achieved only with extrinsic contrast agents that have not been approved for use with humans. In this paper we describe the main limiting factors in visualizing inner retinal cells and the ...

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