1. Assessment of Dermal Wound Repair after Collagen Implantation with Optical Coherence Tomography

    We present an animal study to examine the utility and potential limitations of optical coherence tomography (OCT) for noninvasive evaluation of biomaterial scaffold–assisted wound healing. The transverse and axial resolutions of the OCT system at the wavelength of 1.3 μm were 12 and 10 μm, respectively. A murine full-thickness transcutaneous wound model was employed, in which a 10 mm full-thickness wound was created on the back of each male Balb/cJ mouse and a porous collagen scaffold was implanted in the wound bed followed by coverage with a TegadermTM film. Sequential cross-sectional OCT scans were performed at different ...
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