1. In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

    In search of vulnerable features of coronary plaques with optical coherence tomography: is it time to rethink the current methodological concepts?

    Intravascular optical coherence tomography (OCT) is increasingly being used to assess coronary vessel pathology in vivo due to its unrivalled high resolution of 10–20 µm. Previous reports have shown that OCT is capable of visualizing thin-cap fibroatheromas (TCFAs), 1 which are thought to be the precursor lesions of ruptured plaques responsible for the majority of thrombosis-mediated sudden death. 2 In addition, OCT is able to identify features that have been related to the advancement of atherosclerotic lesions, including neovascularization 3,4 and macrophage infiltration.5,6 It is against this background that Uemura and colleagues describe the baseline OCT ...

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