1. Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

    Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

    Background: To compare the mean central macular thickness (CMT) and the mean average optic nerve retinal nerve fiber layer (RNFL) thickness in the eyes of patients with a history of optic neuritis and/or multiple sclerosis (MS) using 5 commercially available optical coherence tomography (OCT) instruments. Methods: Cross-sectional study including 46 patients (92 eyes) with a history of optic neuritis and/or MS. Both eyes were imaged on the same day with 5 OCT instruments: 1 time-domain OCT (Stratus) and 4 different Fourier-domain (spectral-domain) OCT (3D OCT-1000, Cirrus, RTVue-100, and Spectralis). Results: Twenty-five patients (50 eyes) were included in the ...

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