1. Performance of Automated Drusen Detection by Polarization-sensitive Optical Coherence Tomography

    Performance of Automated Drusen Detection by Polarization-sensitive Optical Coherence Tomography
    Purpose: To estimate the potential of polarization-sensitive optical coherence tomography (PS-OCT) for quantitative assessment of drusen in patients with early age-related macular degeneration (AMD). Methods: Fifteen eyes of thirteen patients presenting drusen consistent with AREDS 2 and 3 classification were examined ophthalmoscopically, followed by fundus photography, autofluorescence imaging and three-dimensional scanning using a PS-OCT. For the automated evaluation of drusen location, area and volume, a novel segmentation algorithm was developed based on the polarization scrambling characteristics of the retinal pigment epithelium (RPE) and applied to each complete dataset. Subsequently, the drusen in each individual B-scan were identified by two independent ...
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