1. Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia

    Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia
    Background and Objectives Optical coherence tomography (OCT) permits high-resolution imaging of tissue subsurfaces up to 2 mm in depth. The purpose of this study was to evaluate the accuracy and reproducibility of OCT in the characterization of cervical intraepithelial neoplasia (CIN) and to distinguish between different CIN grades. Study Design/Materials and Methods Colposcopy-guided OCT images were taken from unsuspicious and suspicious areas in women with suspected CIN. Each woman then underwent directed biopsies. All OCT images were separately evaluated by two blinded investigators and later compared to the corresponding histology based on a 6-grade classification (normal, inflammation, CIN 1 ...
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