1. Assessment of suspicious oral lesions using optical coherence tomography

    Assessment of suspicious oral lesions using optical coherence tomography
    Introduction/aims Optical biopsy systems have been investigated for various clinical applications; however the main interest remains in the diagnosis and monitoring of premalignant and malignant conditions. In this study, we compared findings of optical coherence tomography (OCT) with histopathology results of suspicious oral lesions to assess the feasibility of OCT in identifying pathological tissue. Material/methods Suspicious oral lesions acquired from 120 patients were subjected to immediate ex-vivo Swept-Source Frequency-Domain OCT. Five OCT parameters were assessed (keratin, epithelial, sub-epithelial layers changes, basement membrane and microanatomical structures). Two clinicians and two pathologists, who were blind to clinical and histopathological diagnosis ...
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