1. In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

    In Vivo Comparison of the Optical Clearing Efficacy of Optical Clearing Agents in Human Skin by Quantifying Permeability Using Optical Coherence Tomography

    The objective of the present work is to quantify and compare the optical clearing efficacy of glucose, propylene glycol, glycerol solutions through the human skin tissue in vivo by calculating permeability coefficient of three solutions. Currently, the permeability coefficient of agent in tissues was extracted from OCT amplitude data mainly through the OCT signal slope (OCTSS) and the OCT amplitude (OCTA) methods. In this study, we report the OCT attenuation coefficient (OCTAC) method which is relatively novel and rarely reported methodology to measure the permeability coefficient during the optical skin clearing procedure. The permeability coefficients for 40% propylene glycol, glucose ...

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