1. Optically based-indentation technique for acute rat brain tissue slices and thin biomaterials

    Optically based-indentation technique for acute rat brain tissue slices and thin biomaterials
    Currently, micro-indentation testing of soft biological materials is limited in its capability to test over long time scales due to accumulated instrumental drift errors. As a result, there is a paucity of measures for mechanical properties such as the equilibrium modulus. In this study, indentation combined with optical coherence tomography (OCT) was used for mechanical testing of thin tissue slices. OCT was used to measure the surface deformation profiles after placing spherical beads onto submerged test samples. Agarose-based hydrogels at low-concentrations (w/v, 0.3–0.6%) and acute rat brain tissue slices were tested using this technique over a ...
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