1. Feasibility of Full-field Optical Coherence Microscopy in Ultra-structural Imaging of Human Colon Tissues

    Feasibility of Full-field Optical Coherence Microscopy in Ultra-structural Imaging of Human Colon Tissues
    We demonstrated imaging feasibility of full-field optical coherence microscopy (FF-OCM) in pathological diagnosis of human colon tissues. FF-OCM images enabling high transverse resolution were obtained at different depth of the samples without any dye staining and physical slicing and visualized detailed microstructure of the human colon tissues. Morphological differences in normal tissues, cancer tissues and tissues under transition state were observed and matched with results seen in conventional optical microscope images. The optical biopsy based on FF-OCM could overcome the limitations on the number of physical cutting of tissues and perform high-throughput mass diagnosis of diseased tissues. The proved utility ...
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