1. Detection of Magnetic Particles in Live DBA/2J Mouse Eyes Using Magnetomotive Optical Coherence Tomography

    Detection of Magnetic Particles in Live DBA/2J Mouse Eyes Using Magnetomotive Optical Coherence Tomography

    Objectives: To demonstrate in vivo molecular imaging of the eye using spectral-domain magnetomotive optical coherence tomography (MMOCT).Methods: A custom-built, high-speed, and high-resolution MMOCT was developed for imaging magnetic particle-coupled molecules in living mouse eyes by applying an external dynamic magnetic field gradient during optical coherence tomography (OCT) scanning. The magnetomotive signals were tested in vitro by scanning magnetic beads embedded within an agarose gel (1.5%) and in vivo in the anterior segment of a mouse eye.Results: Cross-sectional OCT images of the gel and the anterior segment of the eye were acquired by regular OCT structural scanning. Magnetomotive ...

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