1. Effect of signal strength on reproducibility of peripapillary retinal nerve fiber layer thickness measurement and its classification by time-domain optical coherence tomography

    Effect of signal strength on reproducibility of peripapillary retinal nerve fiber layer thickness measurement and its classification by time-domain optical coherence tomography
    PURPOSE: To assess the effect of signal strength (SS) on reproducibility of peripapillary retinal nerve fiber layer (RNFL) thickness measurement (measurement agreement) and its color-coded classification (classification agreement) by time-domain optical coherence tomography (OCT). METHODS: Two consecutive Stratus OCT scans with the Fast RNFL protocol were performed in 658 participants. Intraclass correlations and the linear-weighted kappa coefficient were calculated as indicators of RNFL measurement and classification agreement in participants grouped according to the difference in SS between consecutive OCT scans (interscan SS difference). RESULTS: Groups with a larger interscan SS difference (= 2) had lower measurement agreement than those with a ...
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