In Vivo, Dual-Modality OCT/LIF Imaging Using a Novel VEGF Receptor-Targeted NIR Fluorescent Probe in the AOM-Treated Mouse Model
Purpose: Increased vascular endothelial growth factor (VEGF) receptor expression has been
found at the sites of angiogenesis, particularly in tumor growth areas, as compared with
quiescent vasculature. An increase in VEGF receptor-2 is associated with colon cancer
progression. The in vivo detection of VEGF receptor is of interest for the purposes of studying
basic mechanisms of carcinogenesis, making clinical diagnoses, and monitoring the efficacy of
chemopreventive and therapeutic agents. In this study, a novel single chain (sc)VEGF-based
molecular probe is utilized in the azoxymethane (AOM)-treated mouse model of colorectal
cancer to study delivery route and specificity for disease ...
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