1. The Effects of Sildenafil Citrate on Choroidal Thickness As Determined By Enhanced Depth Imaging Optical Coherence Tomography

    The Effects of Sildenafil Citrate on Choroidal Thickness As Determined By Enhanced Depth Imaging Optical Coherence Tomography

    Purpose: To investigate the effects of the phosphodiesterase-5 inhibitor, sildenafil citrate, on choroidal thickness using eye-tracked enhanced depth imaging spectral-domain optical coherence tomography. Methods: In a prospective interventional study, 8 healthy subjects (4 men and 4 women) with no ocular history underwent enhanced depth imaging spectral-domain optical coherence tomography at baseline, 1 hour, and 3 hours after the ingestion of 100 mg of sildenafil citrate. Choroidal thickness measurements for both eyes using enhanced depth imaging spectral-domain optical coherence tomography were taken by 2 masked readers at baseline, 1-hour, and 3-hour time points. Statistical analysis was performed to compare the measurements ...

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