1. Agreement Among Spectral-Domain Optical Coherence Tomography Instruments for Assessing Retinal Nerve Fiber Layer Thickness

    Agreement Among Spectral-Domain Optical Coherence Tomography Instruments for Assessing Retinal Nerve Fiber Layer Thickness

    Purpose:: To assess the agreement of parapapillary retinal nerve fiber layer (RNFL) thickness measurements among 3 spectral-domain optical coherence tomography (SD-OCT) instruments.Design:: Observational, cross-sectional study.Methods:: Three hundred thirty eyes (88 with glaucoma, 206 glaucoma suspects, 36 healthy) from 208 individuals enrolled in the Diagnostic Innovations in Glaucoma Study (DIGS) were imaged using RTVue, Spectralis and Cirrus in a single visit. Agreement among RNFL thickness measurements was assessed using Bland-Altman plots. The influence of age, axial length, disc size, race, spherical equivalent, and disease severity on the pairwise agreements between different instruments was assessed by regression analysis.Results:: Although ...

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