1. Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution

    Full-field optical coherence microscopy for identifying live cancer cells by quantitative measurement of refractive index distribution
    The feasibility of identifying cancer cells by measuring the refractive index (RI) distribution across a single live cell with ultrahigh resolution full-field optical coherence microscopy (FF-OCM) is presented. The FF-OCM is utilized to quantify integral RI distributions of unmodified cells without any cell treatments and used as a biophysical indicator for diagnosing cell malignancy. Firstly, the physical thickness distribution of the cell adherent to a culture dish is measured by taking a series of 0.6 ┬Ám resolved en-face tomograms. Subsequently, from the en-face image of the bottom surface of the cell or the top surface of the dish, the ...
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