1. Local Delivery Versus Intracoronary Infusion of Abciximab in Patients With Acute Coronary Syndromes

    Local Delivery Versus Intracoronary Infusion of Abciximab in Patients With Acute Coronary Syndromes
    Objectives We investigated whether local abciximab delivery to the site of intracoronary thrombus is more effective than intracoronary bolus infusion in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention and downstream clopidogrel administration. Background The intracoronary route of administration does not allow an optimal contact between the plaque components and abciximab, which is rapidly washed out by the coronary flow. Methods A total of 50 patients with ACS and a significant lesion in the culprit artery indicative of local thrombosis were randomly assigned to receive local intracoronary delivery of abciximab through a dedicated perfusion catheter or intracoronary infusion ...
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