1. Depth-Resolved Blood Oxygen Saturation Assessment Using Spectroscopic Common-Path Fourier Domain Optical Coherence Tomography

    Depth-Resolved Blood Oxygen Saturation Assessment Using Spectroscopic Common-Path Fourier Domain Optical Coherence Tomography
    Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength–distance-dependent point spread function (PSF) of OCT’s. Second, to reduce the spectral speckle noise due to the highly scattering ...
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