1. Optical coherence tomography in the evaluation of neurofibromatosis type 1 subjects with optic pathway gliomas

    Introduction: Neurofibromatosis type 1 (NF1) is the most common hereditary neurocutaneous disorder and associated with optic pathway gliomas (OPGs) in ∼15% of affected children. OPGs can be difficult to detect on clinical inspection, often requiring neuro-imaging. Optical coherence tomography (OCT) has been shown to be a useful diagnostic technology in several pediatric eye conditions including glaucoma and idiopathic intracranial hypertension. Our prospective case-series evaluates OCT findings of retinal nerve fiber layer (RNFL) loss from optic atrophy due to OPGs in pediatric NF1 subjects.
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