1. Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography

    Feature Of The Week 3/14/10: Multimodal Imaging with Integrated Photoacoustic Microscopy and Optical Coherence Tomography

    Feature Of The Week 3/14/10: Photoacoustic Ophthalmoscopy (PAOM) is based on Laser-scanning Optical Resolution Photoacoustic Microscopy (LS-OR-PAM), which is a branch of photoacoustic microscopy (PAM). LS-OR-PAM was first developed with the collaboration of Dr. Hao Zhang's lab at University of Wisconsin-Milwaukee and Dr. Shuliang Jiao lab at University of Southern California.

    PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The integrated system can provide optical absorption and scattering contrasts in biological tissues. The multi-modal images are intrinsically registered. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.

    For more information see recent Article. Courtesy Dr. Shuliang Jiao and Dr. Hao Zhang. Click "Full Screen" for better viewing.

      

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