1. Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

    Structural and biochemical characterization of the rat retina with combined Raman spectroscopy-optical coherence tomography (RS-SDOCT)

    Raman spectroscopy (RS) and Optical Coherence Tomography (OCT) are powerful tools for optical analysis of tissues with complimentary strengths. OCT excels and visualizing tissue microstructure while RS can relay tissue biochemical composition. Both instruments have significant potential to serve as valuable tools in non-invasive characterization of the rodent models of retinal disease. In this abstract we present the design and application of a common detector combined RS-OCT instrument for evaluating the morphological and biochemical differences in a rat model for oxygen induced retinopathy. Rat pups that have undergone a variable oxygen treatment are compared to rats raised in room air ...

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