1. The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT

    The study of effects of pore architecture in chitosan scaffolds on the fluid flow pattern by Doppler OCT

    Optimizing and fully understanding the dynamic culture conditions in tissue engineering could accelerate exploration of this new technique into a promising therapy in the medical field. Scaffolds used in tissue engineering usually are highly porous with various pore architecture depending on techniques that manufacture them. Perfusing culture fluid through a scaffold in a bioreactor has proven efficient in enhancing the exchange of nutrients and gas within cell-scaffold constructs. Upon perfusion, flowing fluid in pores inevitably produces shear stress on the wall of the pores, which will in turn induce cellular response for the cells possessing mechanotransducers. Thus, establishing a relationship ...

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