1. Photoacoustic ophthalmoscopy for in vivo retinal imaging

    Photoacoustic ophthalmoscopy for in vivo retinal imaging

    We have developed a non-invasive photoacousticophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. Byusing a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetricimaging of the retinal micro-vasculature and retinal pigment epithelium at ahigh speed. For B-scan frames containing 256 A-lines, the current PAOMhas a frame rate of 93 Hz, which is comparable with state-of-the-artcommercial spectral-domain optical coherence tomography (SD-OCT). Byintegrating PAOM with SD-OCT, we further achieved OCT-guided PAOM,which can provide multi-modal retinal imaging simultaneously ...

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