1. Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss

    Spectral-Domain Optical Coherence Tomography and Adaptive Optics May Detect Hydroxychloroquine Retinal Toxicity Before Symptomatic Vision Loss

    Purpose: To describe spectral-domain optical coherence tomography (SD-OCT) and adaptive optics (AO) imaging in hydroxychloroquine retinal toxicity. Methods: Two patients with long-term hydroxychloroquine use, subtle perifoveal ophthalmoscopic pigmentary changes, and bilateral perifoveal defects on automated Humphrey visual field (HVF) 10-2 perimetry were imaged using SD-OCT and AO. Results: SD-OCT images demonstrated loss of photoreceptor inner segment/outer segment (IS/OS) junction and a downward “sink-hole” displacement of inner retinal structures in areas of hydroxychloroquine toxicity corresponding to HVF 10-2 defects and ophthalmoscopic clinical examination findings. SD-OCT irregularities in the IS/OS junction were also seen in areas not detected on ...

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