Three-dimensional endomicroscopy using optical coherence tomography

Entities Mentioned

• Massachusetts Institute of Technology
• James G. Fujimoto
• Desmond C. Adler
• University of Maryland
• Beth Israel Deaconess Medical Center
• Yu Chen
• LightLab Imaging
• Robert A. Huber
• Ludwig Maximilians Universität München

1. Optical coherence tomography enables micrometre-scale, subsurface imaging of biological tissue by measuring the magnitude and echo time delay of backscattered light. Endoscopic optical coherence tomography imaging inside the body can be performed using fibre-optic probes. To perform three-dimensional optical coherence tomography endomicroscopy with ultrahigh volumetric resolution, however, requires extremely high imaging speeds. Here we report advances in optical coherence tomography technology using a Fourier-domain mode-locked frequency-swept laser as the light source. The laser, with a 160-nm tuning range at a wavelength of 1,315 nm, can produce images with axial resolutions of 5–7 m. In vivo three-dimensional optical coherence tomography endomicroscopy ... (Read Full Article)

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