1. Evaluation of Mouse Models of Colorectal Cancer Using Optical Coherence Tomography and Laser Induced Fluorescence Spectroscopy (Thesis)

    Evaluation of Mouse Models of Colorectal Cancer Using Optical Coherence Tomography and Laser Induced Fluorescence Spectroscopy (Thesis)
    Colorectal cancer (CRC) is the third leading cause of cancer related deaths. Rodent models of CRC are useful for evaluating diagnostic tools, therapeutics, and disease progression; however, an appropriate imaging tool is needed. Optical coherence tomography (OCT) is a non-destructive imaging modality readily packaged into small diameter endoscopes. Using a near- infrared light source, structural images are generated from index of refraction mismatches with resolutions of 2-15 mm at imaging depths of up to 1.3 mm. In contrast, laser-induced fluorescence (LIF) spectroscopy provides information about biochemical composition, exciting tissues with ultraviolet to green wavelengths of light to measure fluorescence ...
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