1. Ultrahigh-Resolution Endoscopic Optical Coherence Tomography for In Vivo Mouse Colonoscopy (Thesis)

    Ultrahigh-Resolution Endoscopic Optical Coherence Tomography for In Vivo Mouse Colonoscopy (Thesis)
    In vivo monitoring of mouse models of colon cancer promises to reduce the cost of research by improving sacrifice timing and allowing serial studies that observe the progression of disease and drug efficacy in a relatively small set of animals. Optical coherence tomography (OCT) is an optical analog of ultrasound imaging, capable of minimally-invasive mapping of light scatter intensity up to 2 mm deep in tissue. In this work, factors limiting resolution in OCT were examined and devices were created and applied to mouse colon imaging that extended the state-of-the-art in endoscopic ultrahigh-resolution OCT. First, axial chromatic aberration of the ...
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