1. Spectral Analysis of Optical Coherence Tomography Signals (Thesis)

    Spectral Analysis of Optical Coherence Tomography Signals (Thesis)

    More than 85% of all cancers originate in the epithelium that lines the internal surfaces of organs throughout the body. Before they become invasive, at stages known as dysplasia and carcinoma in situ, early cancer cells alter the epithelial-cell architecture. More specially, the number of cells, and therefore the number ofnuclei, increases. The nuclei themselves become enlarged and hyperchromatic, i.e. their chromatin changes and colours more darkly when stained during histopathology. Nuclear sizes change from the normal 5 - 10 um to 1:5 - 2 x the size, i.e.10 - 20 um. Currently, these early changes are only detectable ...

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