1. Doppler Fourier Domain Optical Coherence Tomography: A Novel Technique to Analyze Exercise-dependent Changes in Vascular Dynamics of Wild-type and LDL Receptor Knockout Mice in vivo

    Regular exercise is beneficial for the prevention of endothelial dysfunction and atherosclerosis. However, the measurement of changes in vascular dynamics in murine models in vivo is difficult. Therefore, we developed a novel Doppler FD OCT device allowing determination of blood flow in murine arteries and veins with a spectrum read out rate of 12 kHz. The high temporal resolution of the system can be used to quantify the pulse from real-time cross-sectional images by analyzing the intensity alternation caused by changes from systole to diastole inside the vessel lumen. For visualizing of flowing blood in the saphenous artery or vein ...
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