1. Sonophoretic Delivery for Contrast and Depth Improvement in Skin Optical Coherence Tomography

    Our previous studies demonstrated the feasibility of using a sonophoretic delivery method to enhance skin light transmittance with topical application of optical clearing agents using spectroscopy. In this study, we examined the effect of ultrasound [surgeon-performed (SP)] on optical coherence tomography (OCT) imaging depth and contrast of in vitro and in vivo skin. Sixty percent glycerol (G) and SP with a frequency of 1 MHz and a power of 0.75 W over a 3 cm probe was simultaneously applied for 15 min. We find that 60% G/SP results in a twofold increase in achievable OCT imaging depth for ...
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