Nondestructive Quantification of Analyte Diffusion in Cornea and Sclera Using Optical Coherence Tomography

Entities Mentioned

• Valery V. Tuchin
• University of Houston
• Kirill V. Larin
• Saratov State University
• Mohamad G. Ghosn

1. PURPOSE. Noninvasive functional imaging, monitoring, and quantification of analytes transport in epithelial ocular tissues are extremely important for therapy and diagnostics of many eye diseases. In this study the authors investigated the capability of optical coherence tomography (OCT) for noninvasive monitoring and quantification of diffusion of different analytes in sclera and cornea of rabbit eyes. METHODS. A portable time-domain OCT system with wavelength of 1310 ± 15 nm, output power of 3.5 mW, and resolution of 25 µm was used in this study. Diffusion of different analytes was monitored and quantified in rabbit cornea and sclera of whole eyeballs. Diffusion ... (Read Full Article)

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