Nondestructive Quantification of Analyte Diffusion in Cornea and Sclera Using Optical Coherence Tomography

Entities Mentioned

• Valery V. Tuchin
• University of Houston
• Kirill V. Larin
• Saratov State University
• Mohamad G. Ghosn

1. PURPOSE. Noninvasive functional imaging, monitoring, and quantification of analytes transport in epithelial ocular tissues are extremely important for therapy and diagnostics of many eye diseases. In this study the authors investigated the capability of optical coherence tomography (OCT) for noninvasive monitoring and quantification of diffusion of different analytes in sclera and cornea of rabbit eyes. METHODS. A portable time-domain OCT system with wavelength of 1310 ± 15 nm, output power of 3.5 mW, and resolution of 25 µm was used in this study. Diffusion of different analytes was monitored and quantified in rabbit cornea and sclera of whole eyeballs. Diffusion ... (Read Full Article)

   Bookmark or Share this article

   
   

   Related Articles

   • Optical Coherence Tomography versus Stereoscopic Fundus Photography or Biomicroscopy for Diagnosing Diabetic Macular Edema: A Systematic Review
   • also published in iovs.org
   • Advancing on MS: New drugs and hopes for a vaccine.
   • also categorized in Ophthalmology
   • Assessing molecular diffusion in tissues using optical coherence tomography
   • also mentions Valery V. Tuchin
   • The effect of solution concentration on diffusion in scleral tissues
   • also written by Kirill V. Larin
   • Optic neuritis and multiple sclerosis.
   • also categorized in Ophthalmology

   • Great Strides Moved MS Research Forward During 2007
   • also categorized in Ophthalmology
   • Use of varying constraints in optimal 3-D graph search for segmentation of macular optical coherence tomography images.
   • also categorized in Ophthalmology
   • Differential permeability rate and percent clearing of glucose in different regions in rabbit sclera
   • also written by Valery V. Tuchin
   • Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT
   • also written by Kirill V. Larin
   • Central Serous Chorioretinopathy In Patients With Keratoconus.
   • also categorized in Ophthalmology

Login to comment.