Monitoring of glucose permeability in monkey skin in vivo using Optical Coherence Tomography

Entities Mentioned

• Valery V. Tuchin
• University of Houston
• Kirill V. Larin
• Saratov State University
• Mohamad G. Ghosn

1. Topical trans-dermal delivery of drugs has proven to be a promising route for treatment of many dermatological diseases. The aim of this study is to monitor and quantify the permeability rate of glucose solutions in rhesus monkey skin noninvasively in vivo as a primate model for drug diffusion. A time-domain Optical Coherence Tomography (OCT) system was used to image the diffusion of glucose in the skin of anesthetized monkeys for which the permeability rate was calculated. From 5 experiments on 4 different monkeys, the permeability for glucose-20% was found to be (4.41 ± 0.28) 10-6 cm/sec. The results suggest that ... (Read Full Article)

   Bookmark or Share this article

   
   

   Related Articles

   • The effect of solution concentration on diffusion in scleral tissues
   • also written by Kirill V. Larin
   • The Relationship between Visual Field and Retinal Nerve Fiber Layer Measurements in Patients with Multiple Sclerosis.
   • also mentions University of Houston
   • Optical disk readout method using optical coherence tomography and spectral interferometry
   • also categorized in Dermatology
   • Tissue removal using biocompatible materials
   • also categorized in Dermatology
   • Ultra-sensitive monitoring of analyte concentrations using phase sensitive spectral domain OCT
   • also written by Kirill V. Larin

   • Laser treatment of cutaneous vascular lesions
   • also categorized in Dermatology
   • In vivo real time monitoring of vasoconstriction and vasodilation by a combined diffuse reflectance spectroscopy and Doppler optical coherence tomography approach
   • also published in www3.interscience.wiley.com
   • Sunbathing tree frogs' future under a cloud
   • also categorized in Dermatology
   • Assessing molecular diffusion in tissues using optical coherence tomography
   • also mentions Valery V. Tuchin
   • Three-dimensional imaging of artificial fingerprint by optical coherence tomography
   • also written by Kirill V. Larin

Login to comment.