1. Precision of attenuation coefficient measurements by optical coherence tomography

    Precision of attenuation coefficient measurements by optical coherence tomography

    Significance: Optical coherence tomography (OCT) is an interferometric imaging modality, which provides tomographic information on the microscopic scale. Furthermore, OCT signal analysis facilitates quantification of tissue optical properties (e.g., the attenuation coefficient), which provides information regarding the structure and organization of tissue. However, a rigorous and standardized measure of the precision of the OCT-derived optical properties, to date, is missing. Aim: We present a robust theoretical framework, which provides the Cramér -Rao lower bound σμOCT for the precision of OCT-derived optical attenuation coefficients. Approach: Using a maximum likelihood approach and Fisher information, we derive an analytical solution for ...

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