1. Comparison of FAF versus OCT-based evaluation of the therapeutic response to pegcetacoplan in Geographic Atrophy

    Comparison of FAF versus OCT-based evaluation of the therapeutic response to pegcetacoplan in Geographic Atrophy

    Purpose To perform an optical coherence tomography (OCT)-based analysis of geographic atrophy (GA) progression in patients treated with pegcetacoplan. Design Post-hoc analysis of a phase 2 multicenter, randomized, sham-controlled trial Methods Manual annotation of retinal pigment epithelium (RPE), ellipsoid zone (EZ) and external limiting membrane (ELM) loss was performed on OCT volumes from baseline and month 12 from the phase 2 FILLY trial of intravitreal pegcetacoplan for the treatment of GA secondary to age-related macular degeneration. Main Outcome Measures Correlation of GA areas measured on fundus autofluorescence (FAF) and OCT. Difference in square root transformed growth rates of RPE ...

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